Ulcerative colitis
ulcerative-colitis · society: ACG
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Summary
ACG 2025 update to the 2019 UC guideline addresses diagnosis, disease activity assessment, induction/maintenance therapy across mild to severe UC, positioning of newer biologics and small molecules (S1P modulators, JAK inhibitors, IL-23p19 inhibitors), and management of acute severe UC. New features include a defined role for intestinal ultrasound, an updated ACG UC Disease Activity Index, a positioning/sequencing section, and incorporation of bowel urgency as a key patient-reported outcome. Histologic remission is acknowledged as prognostic but not a required target; treat-to-target emphasizes endoscopic improvement (MES 0-1) plus symptomatic remission.
Current guideline: ACG 2025 UC in Adults · 
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Versions
- 2025 · ACG — ACG 2025 UC in Adults
- 2019 · ACG — (no title)
- Read the guideline: html