Cushing’s syndrome

cushings · society: Endocrine Society

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Summary

Endocrine Society 2015 guideline (co-sponsored by European Society of Endocrinology) on the treatment of Cushing’s syndrome. Surgical resection of the causal lesion is first-line for all etiologies (transsphenoidal adenomectomy for Cushing’s disease, unilateral adrenalectomy for benign adrenal disease, resection with nodal dissection for ectopic ACTH). Second-line options — repeat TSS, radiotherapy/radiosurgery, steroidogenesis inhibitors, pituitary-directed agents, glucocorticoid receptor antagonists, and bilateral adrenalectomy — are individualized. Emphasizes aggressive treatment of comorbidities (CV risk, osteoporosis, VTE prophylaxis, infection risk) and lifelong recurrence surveillance.

Current guideline: Endocrine Society 2015 Cushing’s Syndrome Guideline · download Anki sub-deck

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